Dr. Bing-Hung HSUTaiwan
Taipei Medical University –Shuang Ho Hospital
| 2022/12 to present | Attending Physician in the Neurosurgery Department of Taipei Medical University-Shuang Ho Hospital |
| 2023/08 to present | Deputy Secretary-General of Taiwan Society of Middle Youth Neurosurgeon |
| 2023/08 to present | Deputy Secretary-General of Taiwan Neurotrauma and Critical Care Society |
| 2001/09 - 2007/06 | Department of Pharmacy in the Tajen University |
| 2008/10 - 2012/08 | Department of medicine in the Medical University of Silesia |
| 2022/09 - Present | Graduate Institute of clinical Medicine in the Taipei Medical University |
| 2015/08 - 2016/07 | Resident Doctor of Surgical Department in the Taipei Medical University- Wan Fang Hospital |
| 2016/08 - 2021/07 | Resident Doctor of Neurosurgery Department in the Taipei Medical University- Shuang Ho Hospital |
| 2021/08 - 2022/07 | Chief Resident of Neurosurgery Department in the Taipei Medical University- Shuang Ho Hospital |
| 2022/08 - 2022/11 | Fellow doctor of Neurosurgery Department in the Taipei Medical University- Shuang Ho Hospital |
minimal invasive spine surgery，Neurotrauma surgery and Critical Care
Bing-Hung Hsu is an Attending Physician in the Neurosurgery Department of Taipei Medical University's Shuang-Ho Hospital and the Taipei Neuroscience Institute. He is concurrently pursuing a PhD in the Graduate Institute of Clinical Medicine at Taipei Medical University, Taiwan (R.O.C.). Additionally, he serves as the Deputy Secretary-General for both the Taiwan Society of Middle Youth Neurosurgeon and the Taiwan Neurotrauma and Critical Care Society.
Ameliorated extracellular matrix remodeling in intervertebral disc degeneration
1109 13:55-14:05
Spine/304A
Introduction
Disc degeneration refers to chronic lower back pain caused by degeneration of the intervertebral disc, which is usually caused by rotational injury of the intervertebral disc. Intervertebral disc degeneration (IVDD), a condition that forms the basis for numerous spine-related issues, is typified by the extensive breakdown of the extracellular matrix (ECM). The primary proteolytic enzymes implicated in the degradation of the ECM are believed to be Matrix Metalloproteinases (MMPs) and A Disintegrin and Metalloproteinases with Thrombospondin Motifs (ADAMTSs).
While past research has indicated a role for cytokines in the development of intervertebral disc degeneration and herniation, there is still limited knowledge about the targeted treatment of inflammation by inhibiting the HDAC4/ADAMTS-5 axis.
Method
We establish and isolate the Annulus fibrosus (AF) primary cell from the remaining specimens of Intervertebral disc degeneration surgical tissue, and can be used as in vitro model. We isolated and cultured human intervertebral disc circular fibroblasts in vitro. And performed the database research, immunocytochemistry, qPCR and also treated IVDD cells with Tucidinostat , a HDAC inhibitor.
Result
This study employed human annulus fibrosis cell lines induced in inflammatory conditions and in vivo IVD models treated with HDAC4 inhibitor, Tucidinostat. The present study found that HDAC4 and ADAMTS-5 is highly expressed in inflamed human annulus fibrosus cells. Furthermore, employing low dose Tucidinostat effectively reduced ECM degradation enzymes and inflammatory factor via HDAC4/ADAMTS-5 signaling axis.
Conclusion
In vivo experiment showed that Tucidinostat significantly reduced IVD degeneration. Thus, the findings of this study will hopefully be able to divulge the potential of targeting HDAC4/ADAMTS-5 signaling axis in IVD treatment.