Prof. Pin-Yuan CHENTaiwan
Department of Neurosurgery, Chang Gung Memorial Hospital, Keelung. School of Medicine, Chang Gung University
Current Position
2023 to present Chairman of Surgery Department
Academic Experiences
2023 - NowProfessor, Chang Gung University
Professional Experiences
2017 - 2023Chief of Neurosurgical Department
Specialty & Expertise
Awake craniotomy, drug delivery for brain disease
NeuroOncology
About Me
Dr. Pin-Yuan Chen is a highly esteemed professor in the school of medicine at Chang Gung University, Taiwan. He holds a Ph.D. in Clinical Medicine from Chang Gung University and has an extensive background in neurosurgery, with significant contributions to the field of brain tumor treatment and awake craniotomy. Dr. Chen
currently serves as the head of the Department of Surgery at Keelung Chang Gung Memorial Hospital. His research focuses on innovative brain tumor therapies, including drug delivery systems and tumor immunotherapy. He has published over
100 research papers, many of which are in high-impact journals such as the Neuro-Oncology and science advances . Dr. Chen is also an active member of several professional societies, including the Taiwan Neuro-Oncology Society and the American Society of Neuro-Oncology, and has received multiple awards for his clinical innovations and academic contributions.
Presentation Information
Precise functional glioma surgery in CGMH
1108 15:40-15:50
Neuro-oncology/305
In glioma treatment, surgical resection is both a critical and high-risk step. When the lesion invades or is near eloquent areas, achieving maximal resection while preserving as much neurological function as possible is the ideal goal. Intraoperative neurophysiological monitoring under general anesthesia can help ensure motor function, whereas language and complex cognitive functions require electrical stimulation testing under awake condition. Sedative medication during surgery must be managed carefully. Basic intraoperative tasks include counting, naming, and Pyramid and palm tree tests. While continuous subcortical testing during tumor removal is crucial. Customized tasks specific to lesions in different brain regions can be discussed thoroughly with the patient. In cases of recurrence, re-operation by awake craniotomy could help to resect a broader area due to neuroplasticity.
Presentation Information
Developing novel VLP-RNA therapeutics for glioma treatment
1108 16:00-16:10
Neuro-oncology/305
Glioblastoma (GBM) is a grave malignant brain cancer with consistent recurrence after surgical resection followed by chemotherapy and radiotherapy. By using convection-enhanced delivery (CED), we directly administer bioengineered nano Virus-like particles (VLPs) into brain tumors. It was designed to incorporate imaging reporters and accommodate an RNA scaffold called broccoli light-up three-way junction (b-3WJ), which contains two siRNA/miRNA sequences and a light-up aptamer enable gene silencing in radioresistant GBM cells. After Treating with TrQβ@b-3WJLet 7g siEGFR, followed by 2Gy radiation, we could extend the median survival time of glioma-bearing mice from 31 days to over 60 days. These findings show the potential of RNAi-based genetic therapeutics given by CED infusion in enhancing concurrent chemotherapy and radiotherapy for GBMs.